四妙汤加减联合中药外敷治疗湿热蕴结型痛风性关节炎的效果

卢海军 王蒋舟 段璋

福州市长乐区中医院

摘要：目的：探究四妙汤加减联合中药外敷治疗湿热蕴结型痛风性关节炎（GA）患者的临床效果。方法：选取78例急性GA患者，采用随机数字表法分为对照组和观察组，每组各39例。对照组予以常规西药联合中药外敷治疗，观察组在对照组基础上加用四妙汤加减治疗，均连续治疗7 d。结果：观察组治疗总有效率94.87%高于对照组79.49%（P＜0.05）;治疗后，观察组中医证候积分及红细胞沉降率（ESR）、血尿酸（UA）、C反应蛋白（CRP）、白介素-1β（IL-1β）、白介素-6（IL-6）水平均低于对照组（P＜0.05）。治疗期间两组均未见明显不良反应。结论：四妙汤加减联合中药外敷治疗湿热蕴结型GA患者可缓解临床症状，减少炎症渗出，治疗效果好。

关键词：痛风性关节炎;四妙汤;中药外敷;

Effects of modified Simiao decoction combined with external application of Chinese medicine onpatients with heat-damp syndrome of gouty arthritis

LU Haijun,WANG Jiangzhou,DUAN Zhang.(Changle District Hospital of Traditional ChineseMedicine,Fuzhou 350200,China)

Abstract Objective: To investigate the clinical efficacy of modified Simiao decoction combined withexternal application of traditional Chinese medicine in the treatment of patients with heat-damp syndrome ofgouty arthritis(GA). Methods: A total of 78 patients with acute GA were selected and randomized into the control group and the observation group, each with 39 cases. The control group were treated with conventional western medicine combined with external application of Chinese medicine, while the observation group were treated with modified Simiao decoction on this basis. Both groups were treated for 7 days continuously. Results: The clinical total effective rate of the observation group was 94.87%, which was higher than 79. 49% of the control group (P<0.05); after treatment, TCM symptom scores anderythrocyte sedimentation rate(ESR), serum uric acid(UA), C-reactive protein(CRP), interleukin-1β(IL-1β), and interleukin-6(IL-6)levels were lower than those of the control group(P<0.05); and there were no obvious adverse reactions between patients in the two groups during the treatment period.Conclusion: For patients with heat-damp syndrome of GA, the application of modified Simiao decoction combined with external application of Chinese medicine has gained good therapeutic effects, which canrelieve the clinical symptoms, reduce inflammatory exudation and the levels of ESR, UA and CRP in GA patients.

Keywords: gouty arthritis; modified Simiao decoction; external application of Chinese medicine

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