肾病综合征患者经贝前列素钠联合醋酸泼尼松治疗后肾功能、凝血三项指标变化分析

赵晓凯 ^a ,高 杰 ^b

(新郑市中医院 a.内分泌肾内科;b.心血管内科,河南 新郑 451100)

摘要 目的:从肾功能、凝血三项指标等方面探究贝前列素钠联合醋酸泼尼松在肾病综合征(NS)治疗中的应用价值。 方法:选取 95 例 NS 患者,按照随机数字表法分为对照组(n = 47) 和实验组(n=48)。对照组采取醋酸泼尼松治疗,实验组在对照组基础上采取贝前列素钠治疗,连续治疗 3 个月,统计两组临床疗效、不良反应,比较治疗前后肾功能指标[血肌酐(Scr)、尿 β2-微球蛋白(β2-MG)、尿 N-乙酰-β-D-氨基葡萄糖苷酶(NAG)、24 h 尿蛋白排泄率(24 h UPE)]、凝血三项指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)]。 结果:实验组治疗总有效率91.67%高于对照组 72.34%(P<0.05);治疗后,实验组 Scr、24 h UPE、尿 NAG、尿 β2-MG 水平低于对照组(P<0.05);治疗后,实验组 PT、TT、APTT 短于对照组(P<0.05);实验组不良反应总发生率10.42%与对照组 6.38%比较无统计学差异(P>0.05)。 结论:贝前列素钠联合醋酸泼尼松治疗 NS 效果显著,有助于改善凝血三项指标,恢复肾功能,且具有安全性。

关键词: 肾病综合征;贝前列素钠;醋酸泼尼松;肾功能;凝血三项指标

中图分类号:R692　　　　文献标志码:A　　　　文章编号:1008-2409(2022)03-0101-05

Changes of renal function and blood coagulation indexes in patients with nephrotic syndrome after beraprost sodium combined with prednisone acetate treatment

ZHAO Xiaokai ^a , GAO Jie ^b . ( a. Dept. of Endosecretory Nephrology; b. Dept. of Cardiology, Xinzheng Hospital of Traditional Chinese Medicine, Xinzheng 451100, China)

Abstract　Objective: To investigate the application value of beraprost sodium combined with prednisone acetate in patients with nephrotic syndrome(NS)from the three indicators of blood coagulation and renal function. Methods: A prospective study of 95 NS patients was conducted. The patients were randomized into a control group(n = 47) and an experimental group(n = 48). The control group were treated with prednisone acetate, while the experimental group were treated with beraprost sodium on the basis of the control group for three months. Then, the clinical efficacy and adverse reactions were collected and compared between the two groups, and the renal function indexes[serum creatinine(Scr), urinary beta 2-microglobulin(β2-MG), urinary N-acetyl-β-D-glucosaminidase(NAG), 24 h urinary protein excretion rate(24 h UPE)], and blood coagulation indicators [ prothrombin time ( PT ), activated partial thromboplastin time(APTT)and thrombin time(TT)] were compared between the two groups before and after treatment. Results: The total effective rate of the experimental group was 91.67%, which was higher than that of the control group, 72.34%(P<0.05); after treatment, levels of SCR, 24 h UPE, urinary NAG and urinary β2-Mg in the experimental group were lower than those in the control group (P<0.05); PT, TT and APTT of the experimental group were shorter than those of the control group(P<0.05); and there was no statistical significance in the incidence of ADR between the experimental group(10.42%)and the control group(6.38%)(P>0.05). Conclusion: Beraprost sodium combined with prednisone acetate is effective in the treatment of patients with NS, which can improve the indexes of blood coagulation and restore renal function with certain safety.

Keywords: nephrotic syndrome; beraprost sodium; prednisone acetate; renal function; three indicators of blood coagulation

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